Independent Action

Calculate independent action response for a set of chemicals with Hill concentration-response curves.

Usage

calc_independent_action(conc, max, AC50, Emax, n = 1)

Arguments

conc

concentrations in regular space

max

maximal (asymtotic) responses

AC50

concentrations of half-maximal response

Emax

maximum mixture response

n

Hill coefficients (slopes)

Value

response value

Details

The concentration is computed as: $$ IA = E_{max} \left( 1 - \prod\limits_{i} \left(1 - \frac{x_i}{E_{max}}\right) \right), $$ where \(x_i = hill\_val(conc_i, max_i, AC50_i, n_i)\) is the Hill model response function for each chemical.

See also

hill_val