Calculate in vitro concentration — calc_invitro

Estimate the in vitro equivalent plasma concentration given internal chemical dose and steady-state plasma concentration.

Usage

calc_invitro_concentration(D_int, C_ss = NULL)

Arguments

D_int: internal chemical dose in $\frac{mg}{kg}$
C_ss: steady-state plasma concentration in $\frac{\mu M}{mg / kg}$

Value

list of matrices containing concentrations in $\mu M$

Details

Input D_int must be a matrix or list of matrices. Input C_ss must be a numeric atomic vector or matrix, or a list of those types.

The in vitro equivalent plasma concentration is calculated as: $$C_{plasma} = C_{ss} \times D_{int}$$

Examples

# Single population
D_int <- matrix(1:15, ncol = 3)
C_ss <- 1:5
calc_invitro_concentration(D_int, C_ss)
#> [[1]]
#>      [,1] [,2] [,3]
#> [1,]    1    6   11
#> [2,]    4   14   24
#> [3,]    9   24   39
#> [4,]   16   36   56
#> [5,]   25   50   75
#> 

# Multiple populations
D_int <- list(
  "a" = matrix(1:15 / 10, ncol = 3),
  "b" = matrix(1:8, ncol = 2)
)
C_ss <- list(1:5, 1:4 / 2)
calc_invitro_concentration(D_int, C_ss)
#> $a
#>      [,1] [,2] [,3]
#> [1,]  0.1  0.6  1.1
#> [2,]  0.4  1.4  2.4
#> [3,]  0.9  2.4  3.9
#> [4,]  1.6  3.6  5.6
#> [5,]  2.5  5.0  7.5
#> 
#> $b
#>      [,1] [,2]
#> [1,]  0.5  2.5
#> [2,]  2.0  6.0
#> [3,]  4.5 10.5
#> [4,]  8.0 16.0
#>